A microphone preamplifier circuit is provided in a system on chip. An amplifier comprises a first input end, a second input end, and an output end. A bias voltage is provided by a bias voltage source. A first sensor is coupled to the first input end and the bias voltage source for sensing a first physical parameter and a second physical parameter. A second sensor is coupled to the second input end and the bias voltage source for sensing the first physical parameter, wherein the second sensor is insensitive to the second physical parameter. The output end of the amplifier outputs a difference of the first and second input ends whereby noises and interferences are reduced.