发明申请
US20100184746A1 LINCOSAMIDE DERIVATIVES AND ANTIMICROBIAL AGENTS COMPRISING THE SAME AS ACTIVE INGREDIENT
失效
林酰胺衍生物和包含它们作为活性成分的抗微生物剂
- 专利标题: LINCOSAMIDE DERIVATIVES AND ANTIMICROBIAL AGENTS COMPRISING THE SAME AS ACTIVE INGREDIENT
- 专利标题(中): 林酰胺衍生物和包含它们作为活性成分的抗微生物剂
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申请号: US12451752申请日: 2008-05-30
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公开(公告)号: US20100184746A1公开(公告)日: 2010-07-22
- 发明人: Eijirou Umemura , Kou Kumura , Satomi Masaki , Kazutaka Ueda , Yoshinari Wakiyama , Yasuo Sato , Mikio Yamamoto , Keiichi Ajito , Takashi Watanabe , Chizuko Kaji
- 申请人: Eijirou Umemura , Kou Kumura , Satomi Masaki , Kazutaka Ueda , Yoshinari Wakiyama , Yasuo Sato , Mikio Yamamoto , Keiichi Ajito , Takashi Watanabe , Chizuko Kaji
- 专利权人: Meiji Seika Kaisha Ltd
- 当前专利权人: Meiji Seika Kaisha Ltd
- 优先权: JP2007146200 20070531
- 国际申请: PCT/JP2008/060045 WO 20080530
- 主分类号: A61K31/55
- IPC分类号: A61K31/55 ; C07D405/14 ; A61K31/506 ; C07D405/02 ; A61K31/4025 ; C07D401/02 ; A61K31/4439 ; C07D285/12 ; A61K31/433 ; C07D413/14 ; A61K31/422 ; A61K31/501 ; A61K31/496 ; A61K31/5377 ; A61P31/04 ; A61P11/00
摘要:
An objective of the present invention is to provide compounds of formula (I) or their pharmacologically acceptable salts or solvates wherein A represents aryl while R1 represents a five- or six-membered monocyclic heterocyclic group, or A represents a four- to six-membered monocyclic heterocyclic group while R1 represents aryl or a five- or six-membered monocyclic heterocyclic group; R2 represents a hydrogen atom or C1-6 alkyl; R3 represents C1-6 alkyl or C3-6 cycloalkyl-C1-4 alkyl; R4, R5, and R6 represent a hydrogen atom; R7 represents C1-6 alkyl; and m is 1 to 3. The compounds are novel lincosamide derivatives that have a potent activity against resistant Streptococcus pneumoniae. Further, the compounds are usable as antimicrobial agents and are useful for preventing or treating bacterial infectious diseases.
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