A droplet ejection apparatus includes a common flow path; droplet ejection units each respectively including a first distribution port; first flow paths that respectively connect each first distribution port to the common flow path; first open/close mechanisms provided respectively at the first flow paths; a first pressurizing unit that applies a positive pressure to the common flow path; a second open/close mechanisms provided at the common flow path at the first pressurizing unit side of connection portions that connect the common flow path and the respective first flow paths; and a controller. When the second open/close mechanism is closed, the controller opens only one or more first open/close mechanisms corresponding to one or more target droplet ejection units, applies positive pressure to a section of the common flow path at the first pressurizing unit side of the second open/close mechanism, and then opens the second open/close mechanism.