发明申请
US20100190928A1 POLYMERIC CONJUGATES OF DOXORUBICIN WITH PH-REGULATED RELEASE OF THE DRUG AND A METHOD OF PREPARING
审中-公开
DOXORUBICIN与药物PH调节释放的聚合物及其制备方法
- 专利标题： POLYMERIC CONJUGATES OF DOXORUBICIN WITH PH-REGULATED RELEASE OF THE DRUG AND A METHOD OF PREPARING
- 专利标题（中）： DOXORUBICIN与药物PH调节释放的聚合物及其制备方法
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申请号： US12376915申请日： 2007-08-08
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公开(公告)号： US20100190928A1公开(公告)日： 2010-07-29
- 发明人: Tomas Etrych , Karel Ulbrich
- 申请人： Tomas Etrych , Karel Ulbrich
- 优先权： CZPV2006-505 20060809
- 国际申请： PCT/CZ07/00077 WO 20070808
- 主分类号： A61K47/48
- IPC分类号： A61K47/48
摘要：
A polymeric drug in the form of a conjugate of a copolymer of N-(2-hydroxypropyl)-methacrylamide (HPMA) with doxorubicin bound to the polymer via spacers containing hydrolytically cleavable hydrazone bonds, of formula (I), wherein SP1 represents an aminoacyl spacer, x=40 to 335, y=1 to 25, consisting of from 90 to 99.5 mol. % of units of HPMA and 10 to 0.5 mol. % of doxorubicin-containing comonomeric units. The conjugate is prepared via direct copolymerization of the doxorubicin-containing monomer of formula (II) with HPMA.
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