A mobile station includes a transmission chain capable of communicating via an uplink transmission to at least one base station in a Multiple Input Multiple Output wireless network. The mobile station includes a plurality of transmit antenna and a transmitter coupled to the plurality of transmit antenna. The transmitter includes a layer mapper that maps data and uplink control information to at least one layer. The mapping is performed prior to Discrete Fourier Transform precoding such that the data and uplink control information are multiplexed and interleaved. The transmitter is configured to simultaneously transmit the data and uplink control information on at least one of a plurality of transmission layers.