发明申请
- 专利标题： Method of inhibition of vascular development using an antibody
- 专利标题（中）： 使用抗体抑制血管发育的方法
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申请号： US12317074申请日： 2008-12-17
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公开(公告)号： US20100196361A1公开(公告)日： 2010-08-05
- 发明人: Clive R. Wood , Daniel T. Dransfield , Henk Pieters , Rene Hoet , Simon E. Hufton
- 申请人： Clive R. Wood , Daniel T. Dransfield , Henk Pieters , Rene Hoet , Simon E. Hufton
- 申请人地址： US MA Cambridge
- 专利权人： DYAX CORP.
- 当前专利权人： DYAX CORP.
- 当前专利权人地址： US MA Cambridge
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/18 ; A61P35/04
摘要：
Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial cell activity and angiogenesis. The agents can be used to treat angiogenesis-associated disorders.