发明申请
US20100197899A1 SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDES COMPRISING A 2-ARYLPROPYL MOIETY
有权
包含2-ARYLPROPYL MOIETY的单链和双链寡核苷酸
- 专利标题： SINGLE-STRANDED AND DOUBLE-STRANDED OLIGONUCLEOTIDES COMPRISING A 2-ARYLPROPYL MOIETY
- 专利标题（中）： 包含2-ARYLPROPYL MOIETY的单链和双链寡核苷酸
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申请号： US12604897申请日： 2009-10-23
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公开(公告)号： US20100197899A1公开(公告)日： 2010-08-05
- 发明人: Muthiah MANOHARAN , Kallanthottathil G. Rajeev , Vekitasamy Kesavan
- 申请人： Muthiah MANOHARAN , Kallanthottathil G. Rajeev , Vekitasamy Kesavan
- 申请人地址： US MA Cambridge
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人地址： US MA Cambridge
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C07H21/02
摘要：
The present invention provides single-stranded and double-stranded oligonucleotides comprising at least one aralkyl ligand that improvise the pharmacokinetic properties of the oligonucleotide. The aralkyl ligands of the present invention include naproxen, ibuprofen, and derivatives thereof. The present invention also provides method for modulating gene expression using the modified oligonucleotide compounds and compositions comprising those modified oligonucleotides.
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