发明申请
US20100204124A1 Compositions and Methods for Minimally-Invasive Systemic Delivery of Proteins Including TGF-Beta Superfamily Members
审中-公开
包含TGF-β超家族成员的蛋白质微创系统递送的组成和方法
- 专利标题： Compositions and Methods for Minimally-Invasive Systemic Delivery of Proteins Including TGF-Beta Superfamily Members
- 专利标题（中）： 包含TGF-β超家族成员的蛋白质微创系统递送的组成和方法
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申请号： US12705367申请日： 2010-02-12
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公开(公告)号： US20100204124A1公开(公告)日： 2010-08-12
- 发明人: Mary Elizabeth Pecquet Goad , Denis Schrier , Allen Richard Pierce
- 申请人： Mary Elizabeth Pecquet Goad , Denis Schrier , Allen Richard Pierce
- 主分类号： A61K38/19
- IPC分类号： A61K38/19 ; A61P19/02 ; A61P19/04 ; A61P1/16 ; A61P13/12 ; A61P9/10 ; A61P25/16 ; A61P27/02 ; A61P3/10 ; A61P3/04 ; A61P35/00 ; A61P29/00 ; A61M25/00
摘要：
The present invention is directed to methods and compositions for systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the TGF-β superfamily. According to the invention, an exemplary bioactive agent is BMP-7 The invention further provides for minimally-invasive systemic treatment of skeletal disorders such as osteoporosis as well as minimally-invasive systemic treatment of injured or diseased non-mineralized tissues and organs such kidneys. Practice of the invention eliminates adverse side effects at the site of intravascular delivery of the bioactive agent.
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