发明申请
- 专利标题： INHIBITORS OF CATHEPSIN S
- 专利标题（中）： CATHEPSIN的抑制剂
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申请号： US12764772申请日： 2010-04-21
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公开(公告)号： US20100204200A1公开(公告)日： 2010-08-12
- 发明人: Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
- 申请人： Hong Liu , Arnab Chatterjee , David C. Tully , Phillip Alper , Badry Bursulaya , Jianhua Guo , David H. Woodmansee , Daniel Mutnick , Donald S. Karanewsky , Yun He
- 申请人地址： BM Hamilton
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： BM Hamilton
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D413/12 ; C07D295/145 ; C07D413/14 ; C07C245/00 ; C07D401/12 ; C07D403/12 ; A61K31/5375 ; A61K31/54 ; A61K31/496 ; A61K31/404
摘要：
The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme. The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S. More particularly, the present invention provides compounds having Formula 1: wherein Q is an optionally substituted azetidinyl, pyrrolidinyl, piperidyl, and indolinyl; or Q is NR25R26; and A, R5, R6, R7, R8, R9, R25, R26 and Ar are substituents.