- 专利标题： Substituted imidazoles as bombesin receptor subtype-3 modulators
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申请号： US12311672申请日： 2007-10-16
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公开(公告)号： US20100204236A1公开(公告)日： 2010-08-12
- 发明人: Peter H. Dobbelaar , Christopher L. Franklin , Allan Goodman , Cheng Guo , Peter R. Guzzo , Mark Hadden , Shuwen He , Alan J. Henderson , Tianying Jian , Linus S. Lin , Jian Liu , Ravi P. Nargund , Megan Ruenz , Bruce J. Sargent , Iyassu K. Sebhat , Larry Yet
- 申请人： Peter H. Dobbelaar , Christopher L. Franklin , Allan Goodman , Cheng Guo , Peter R. Guzzo , Mark Hadden , Shuwen He , Alan J. Henderson , Tianying Jian , Linus S. Lin , Jian Liu , Ravi P. Nargund , Megan Ruenz , Bruce J. Sargent , Iyassu K. Sebhat , Larry Yet
- 国际申请： PCT/US2007/022081 WO 20071016
- 主分类号： A61K31/4178
- IPC分类号： A61K31/4178 ; A61K31/4985 ; A61K31/501 ; A61K31/497 ; A61K31/506 ; A61K31/4439 ; A61K31/427 ; A61K31/425 ; A61K31/4196 ; A61K31/4164 ; C07D471/04 ; C07D401/10 ; C07D417/10 ; C07D405/10 ; C07D403/10 ; C07D409/06 ; C07D233/64 ; A61P9/10 ; A61P3/04
摘要：
Certain novel substituted imidazoles are ligands of the human bombesin receptor and, in particular, are selective ligands of the human bombesin receptor subtype-3 (BRS-3). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of BRS-3, such as obesity, and diabetes.