An ESD protection circuit coupled between a first power line and a second power line to avoid damage to an integrated circuit by an ESD event is disclosed. The ESD protection circuit includes a detection unit, a trigger unit, and a discharging unit. The detection unit asserts a detection signal when the ESD event occurs. The trigger unit asserts a first trigger signal and a second trigger signal when the detection is asserted. The discharging unit provides a discharge path to release an ESD current caused by the ESD event when the first and the second trigger signals are asserted.