Embodiments of the present invention provide a signal transmission method and apparatus used in an Orthogonal Frequency Division Multiple Access (OFDMA) wireless communication system, to enhance stability of signal transmission and resist time-frequency dispersion. The signal transmission method used in the OFDMA wireless communication system provided by an embodiment of the invention includes: converting an L×1 symbol vector into an N×1 modulating signal vector according to a loading factor fed back by a receiving party, in which value of N is known, both L and N are natural numbers larger than one, N is larger than or equal to L, the loading factor is a ratio of L and N; mapping the N×1 modulating signal vector into N time-frequency grids; and converting the N time-frequency grids into a signal waveform and sending the signal waveform to the receiving party.