发明申请
US20100210595A1 SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS
有权
取代的芳基磺酰氨基乙基磷酸衍生物，其制备及其在治疗I型和II型糖尿病的用途
- 专利标题： SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS
- 专利标题（中）： 取代的芳基磺酰氨基乙基磷酸衍生物，其制备及其在治疗I型和II型糖尿病的用途
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申请号： US12669979申请日： 2008-07-25
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公开(公告)号： US20100210595A1公开(公告)日： 2010-08-19
- 发明人: Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
- 申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
- 申请人地址： DE Ingelheim am Rhein
- 专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人： BOEHRINGER INGELHEIM INTERNATIONAL GMBH
- 当前专利权人地址： DE Ingelheim am Rhein
- 优先权： DE102007035334.2 20070727
- 国际申请： PCT/EP08/59807 WO 20080725
- 主分类号： A61K31/675
- IPC分类号： A61K31/675 ; C07F9/572 ; C07F9/6541 ; C07F9/653 ; C07F9/6533 ; C07F9/6558 ; A61K31/683 ; C07F9/59 ; C07F9/6509 ; A61P3/10
摘要：
The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.