发明申请
US20100210664A1 BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR
审中-公开
适用于治疗多巴胺D3受体调节障碍的苯并呋喃半导体化合物
- 专利标题: BENZENESULFONAMIDE COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MODULATION OF THE DOPAMINE D3 RECEPTOR
- 专利标题(中): 适用于治疗多巴胺D3受体调节障碍的苯并呋喃半导体化合物
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申请号: US12666627申请日: 2008-10-30
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公开(公告)号: US20100210664A1公开(公告)日: 2010-08-19
- 发明人: Sean Colm Turner , Andreas Haupt , Wilfred Braje , Udo Lange , Karla Drescher , Liliane Unger , Ana Lucia Jongen-Relo , Bespalov Anton
- 申请人: Sean Colm Turner , Andreas Haupt , Wilfred Braje , Udo Lange , Karla Drescher , Liliane Unger , Ana Lucia Jongen-Relo , Bespalov Anton
- 优先权: EP07119788.3 20071031
- 国际申请: PCT/EP2008/064732 WO 20081030
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; C07D401/04 ; A61P25/00 ; A61P25/30 ; A61P25/18
摘要:
The invention relates to compounds of the formula R1 is selected from the group consisting of hydrogen, linear C1-C3 alkyl and fluorinated linear C1-C3 alkyl; R2 is hydrogen or methyl; R3 is selected from the group consisting of hydrogen, halogen, C1-C2-alkyl, fluorinated C1-C2-alkyl, C1-C2-alkoxy and fluorinated C1-C2-alkoxy, R4 is C1-C2-alkyl or fluorinated C1-C2-alkyl; n is 0, 1 or 2, and the physiologically tolerated salts of these compounds and the N-oxides thereof. The invention also relates to a pharmaceutical composition that comprises at least one compound of the formula I and/or at least one physiologically tolerated acid addition salt thereof, and further to a method for treating disorders that respond beneficially to dopamine D3 receptor antagonists or dopamine D3 agonists, said method comprising administering an effective amount of at least one compound or physiologically tolerated acid addition salt of the formula I to a subject in need thereof.
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