发明申请
US20100210672A1 AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS
失效
AZABICYCLO [3。 作为DOPAMINE D3受体的调节剂的HEXYL衍生物
- 专利标题: AZABICYCLO [3. 1. O] HEXYL DERIVATIVES AS MODULATORS OF DOPAMINE D3 RECEPTORS
- 专利标题(中): AZABICYCLO [3。 作为DOPAMINE D3受体的调节剂的HEXYL衍生物
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申请号: US12680785申请日: 2008-10-01
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公开(公告)号: US20100210672A1公开(公告)日: 2010-08-19
- 发明人: Barbara Bertani , Francesca Cardullo , Paolo Dambruoso , Paola Marzorati , Fabrizio Micheli , Alessandra Pasquarello , Catia Seri , Giovanna Tedesco
- 申请人: Barbara Bertani , Francesca Cardullo , Paolo Dambruoso , Paola Marzorati , Fabrizio Micheli , Alessandra Pasquarello , Catia Seri , Giovanna Tedesco
- 专利权人: Glaxo Group Limited
- 当前专利权人: Glaxo Group Limited
- 优先权: GB0719235.4 20071002
- 国际申请: PCT/EP08/63166 WO 20081001
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D403/14 ; A61P25/18 ; A61P25/30
摘要:
The present invention relates to novel compounds of formula (I) or a salt thereof: whereinR1 is a 5-membered heteroaryl group, optionally fused with a 6-membered hetero or carbocycle; such 5 or 11-membered system, may be optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, C1-4alkanoyl, haloC1-4alkoxy and SF5; and n is 1 or 2; their use in therapy, as modulators of dopamine D3 receptors, e.g. to treat drug dependency, as antipsychotic agents, to treat obsessive compulsive spectrum disorders, or premature ejaculation.