A method allocates resource in an Orthogonal Frequency-Division Multiple Access (OFDMA) network, including a set of Base Stations (BSs) and a set of Mobile Stations (MSs) for each BS. OFDMA frame are constructed as multiple resource blocks, and each resource block contains symbols transmitted on different subcarriers. A cluster is formed from adjacent sectors of different neighboring cells to jointly optimize the resource allocation in multiple frames, and three non-overlap zones are sequentially identified in cluster: cell center zone, cell edge zone, and cluster corner zone. Resource allocation includes intra-cluster proportional fair scheduling and inter-cluster interference mitigation. Intra-cluster scheduling further includes resource allocation for cell center zone and resource allocation for cell edge zone.