发明申请
- 专利标题： Pegylated Single-Chain Insulin
- 专利标题（中）： 聚乙二醇化单链胰岛素
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申请号： US11908646申请日： 2006-03-17
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公开(公告)号： US20100216690A1公开(公告)日： 2010-08-26
- 发明人: Peter Madsen , Thomas Borglum Kjeldsen
- 申请人： Peter Madsen , Thomas Borglum Kjeldsen
- 申请人地址： DK Baagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DK Baagsvaerd
- 优先权： DKPA200500400 20050318
- 国际申请： PCT/EP06/60816 WO 20060317
- 主分类号： A61K38/28
- IPC分类号： A61K38/28 ; C07K14/62 ; A61P3/10
摘要：
The present invention is related to a single-chain insulin comprising the B- and the A-chain of human insulin or analogues thereof connected by a connecting peptide having from 3-35 amino acid residues, wherein the single-chain insulin comprises at least one PEG group attached to at least one lysine residue in the single-chain insulin molecule and/or to the B1 N terminal amino acid residue. The PEGylated single-chain insulins may comprise up to 4 PEG groups which may be the same or different.
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