发明申请
US20100216780A1 NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
有权
新的1,4-二氮杂双环[3.2.2]壬基氧杂环丁烷衍生物及其医疗用途
![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE](/docs/US/2010-08-26/US20100216780A1/abs.jpg.600x600.jpg)
- 专利标题： NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE
- 专利标题（中）： 新的1,4-二氮杂双环[3.2.2]壬基氧杂环丁烷衍生物及其医疗用途
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申请号： US12297333申请日： 2007-05-29
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公开(公告)号： US20100216780A1公开(公告)日： 2010-08-26
- 发明人: Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Timo Dyhring
- 申请人： Dan Peters , Gunnar M. Olsen , Elsebet Østergaard Nielsen , Daniel B. Timmermann , Steven Charles Loechel , Jens Damsgaard Mikkelsen , Henrik Björk Hansen , John Paul Redrobe , Jeppe Kejser Christensen , Timo Dyhring
- 优先权： DKPA200600731 20060530
- 国际申请： PCT/EP2007/055168 WO 20070529
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; C07D471/08 ; A61P25/00 ; A61P25/28 ; A61P25/24 ; A61P25/18 ; A61P25/22 ; A61P29/00 ; A61P17/10 ; A61P11/06 ; A61P1/00
![NOVEL 1,4-DIAZA-BICYCLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES AND THEIR MEDICAL USE](/abs-image/US/2010/08/26/US20100216780A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
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