发明申请
US20100222259A1 Compositions for enhancing the production of PPAR and/or PPAR-associated factors 审中-公开
用于增强PPAR和/或PPAR相关因子产生的组合物

  • 专利标题: Compositions for enhancing the production of PPAR and/or PPAR-associated factors
  • 专利标题(中): 用于增强PPAR和/或PPAR相关因子产生的组合物
  • 申请号: US11631745
    申请日: 2005-04-01
  • 公开(公告)号: US20100222259A1
    公开(公告)日: 2010-09-02
  • 发明人: Hidekazu AraiEiji TakedaHajime Sasaki
  • 申请人: Hidekazu AraiEiji TakedaHajime Sasaki
  • 优先权: JP2004-203539 20040709; JP2004-290843 20041001
  • 国际申请: PCT/JP05/06461 WO 20050401
  • 主分类号: A61K38/16
  • IPC分类号: A61K38/16 A61P3/10 A61P3/04
Compositions for enhancing the production of PPAR and/or PPAR-associated factors
摘要:
The present inventors focused on certain nutritional compositions known to have activity of controlling blood glucose levels. These foods were administered to rats for long periods, and real-time PCR was used to analyze the expression of genes associated with lipid metabolism in the liver and adipose tissues. As a result, the present inventors found that the expression of the PPARα gene is enhanced by these foods, and that this is accompanied by suppressed expression of fatty acid synthase and enhanced expression of a group of PPARα target genes associated with fatty acid metabolism. The present inventors also confirmed the effect of these foods in enhancing the expression of PPARγ and adiponectin, and discovered that these foods have the activity of enhancing the production of PPAR and PPAR-associated factors.
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