发明申请
- 专利标题： MODULATION OF GLUCOCORTICOID RECEPTOR EXPRESSION
- 专利标题（中）： 葡萄糖激素受体表达的调节
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申请号： US12687533申请日： 2010-01-14
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公开(公告)号： US20100222412A1公开(公告)日： 2010-09-02
- 发明人: Brett P. Monia , Robert McKay , Susan M. Freier , Sanjay Bhanot , Lynnetta Watts
- 申请人： Brett P. Monia , Robert McKay , Susan M. Freier , Sanjay Bhanot , Lynnetta Watts
- 申请人地址： US CA Carlsbad
- 专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人： Isis Pharmaceuticals, Inc.
- 当前专利权人地址： US CA Carlsbad
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/04 ; C12N5/02 ; A61P3/00 ; A61P7/12 ; A61P3/04
摘要：
Compounds, compositions and methods are provided for modulating the expression of glucocorticoid receptor. The compositions comprise antisense compounds, particularly antisense oligonucleotides which have particular in vivo properties, targeted to nucleic acids encoding glucocorticoid receptor. Methods of using these compounds for modulation of glucocorticoid receptor expression and for treatment of diseases are provided.
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