发明申请
US20100227864A1 5-MEMBERED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
有权
5成分的杂环衍生物及其用于医疗用途的用途
- 专利标题: 5-MEMBERED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES
- 专利标题(中): 5成分的杂环衍生物及其用于医疗用途的用途
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申请号: US12595437申请日: 2008-04-10
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公开(公告)号: US20100227864A1公开(公告)日: 2010-09-09
- 发明人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人: Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
- 申请人地址: JP Matsumoto-shi, Nagano
- 专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人: KISSEI PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Matsumoto-shi, Nagano
- 优先权: JP2007-104094 20070411
- 国际申请: PCT/JP2008/057093 WO 20080410
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D231/10 ; A61K31/4155 ; C07D413/06 ; C07D401/04 ; A61K31/4412 ; A61P43/00
摘要:
The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to 5-membered heterocyclic derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, haloalkyl and the like; X1 and X2 independently represent CR2 or N; R2 represents H, alkyl and the like; R1 represents halogen, cyano, haloalkyl, A-D-E-G-L-M, -N(-D-L-M)2 and the like, in the formula, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SO2 and the like.