发明申请
- 专利标题： Oligomer-Beta Blocker Conjugates
- 专利标题（中）： 寡聚体-β阻滞剂缀合物
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申请号： US12530412申请日： 2008-03-12
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公开(公告)号： US20100227865A1公开(公告)日： 2010-09-09
- 发明人: Jennifer Riggs-Sauthier , Franco J. Duarte , Aaron S. Hammons
- 申请人： Jennifer Riggs-Sauthier , Franco J. Duarte , Aaron S. Hammons
- 国际申请： PCT/US08/03352 WO 20080312
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07C217/64 ; A61K31/138 ; C07C235/34 ; C07C229/34 ; A61K31/222 ; C07D417/04 ; A61P9/12 ; A61P25/06 ; A61P9/10 ; A61P25/22 ; A61P25/24
摘要：
The invention provides Beta-blocker drugs that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits a different biological membrane crossing rate as compared to the biological membrane crossing rate of the Beta-blocker drug not attached to the water soluble oligomer.
公开/授权文献
- US09782488B2 Oligomer-beta blocker conjugates 公开/授权日：2017-10-10
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