A self defense spray device comprising a spray unit having a spray canister with an irritant spray, a nozzle operable to release the irritant spray, and a first connector attached to the spray canister. The device further includes a holder having a second connector adapted to releasably engage the first connector to releasably connect the spray unit to the holder, and a safety mechanism that prevents the nozzle from releasing the spray when the spray unit is connected to the holder, thus disarming the device. Once the spray unit is removed from the holder, the safety no longer blocks the nozzle thus arming the device.