In a method and device to evaluate a time series of in particular two-dimensional images of a contrast agent flow in at least one blood vessel of the human body within the scope of a test bolus measurement, wherein the acquisition of the time series begins with administration of the contrast agent, the time series of two-dimensional images or a time series of images derived from this is used as a time series of evaluation images, and in at least one evaluation image exhibiting a contrast agent signal, at least one point associated with a blood vessel is determined semi-automatically or automatically and transferred to further evaluation images. For every blood vessel discovered in this way, a temporal contrast agent course curve is determined (in particular via a fit) automatically from the image signal of the evaluation images at the at least one point and/or in a region around the marked point in the blood vessel and at least one item of contrast agent information that affects the temporal workflow of a subsequent measurement is determined from at least one contrast agent course curve.