Aspects of a method and system for mitigating interference between a plurality of femtocells utilizing transmission deferral are provided. In this regard, prior to transmission of cellular signals by a femtocell, the femtocell may be operable to detect signals that interfere with cellular communications between the femtocell, one or more base stations, and a cellular enabled communication device that communicates with the femtocell. The femtocell may be operable to defer transmission of the cellular signals for a particular period of time based on the detected interfering signals. During transmission of cellular signals from the femtocell to a cellular enabled communication device, the femtocell may be operable to detect loss of one or more packets of data. The femtocell may be operable to defer transmission of the cellular signals for a particular period of time based on the detected loss of one or more packets of data.