The present invention relates to a composition comprising a combination of at least one natural or synthetic β-glycolipid, a mixture of at least two β-glycolipids, a substance which increases the intracellular, extracellular or serum level of a naturally occurring β-glycolipid, or any combination or mixture thereof and at least one phosphate inhibitor or any compound that alters the phosphate binding or transporting into or out of any cell or any membrane or any combination thereof. The combined composition of the invention may be particularly used for treating calcification related degenerative disorders, specifically, vascular and valvular disorders. The invention further provides kits methods and uses thereof for treatment of calcification related disorders.