发明申请
US20100249052A1 DSRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTIONS
审中-公开
DSRNA组合物和治疗HPV感染的方法
- 专利标题： DSRNA COMPOSITIONS AND METHODS FOR TREATING HPV INFECTIONS
- 专利标题（中）： DSRNA组合物和治疗HPV感染的方法
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申请号： US12593202申请日： 2008-03-25
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公开(公告)号： US20100249052A1公开(公告)日： 2010-09-30
- 发明人: John Benson , Kevin Fitzgerald , Birgit Bramlage , Pamela Tan , Hans-Peter Vornlocher
- 申请人： John Benson , Kevin Fitzgerald , Birgit Bramlage , Pamela Tan , Hans-Peter Vornlocher
- 专利权人： Alnylam Pharmaceuticals, Inc.
- 当前专利权人： Alnylam Pharmaceuticals, Inc.
- 国际申请： PCT/EP08/53475 WO 20080325
- 主分类号： C12N15/86
- IPC分类号： C12N15/86 ; C07H21/02 ; A61K31/7088
摘要：
The invention relates to a double-stranded ribonucleic acid (dsRNA) for treating human papilloma virus (HPV) infection. The dsRNA comprises an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of an HPV Target gene selected from the human E6AP gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier; methods for treating diseases caused by HPV infection and the expression of the E6AP gene using the pharmaceutical composition; and methods for inhibiting the expression of the HPV Target genes in a cell.
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