发明申请
US20100249192A1 NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
审中-公开
作为维生素D的抑制剂的新型异构化合物DELTA-9去饱和酶
- 专利标题： NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE
- 专利标题（中）： 作为维生素D的抑制剂的新型异构化合物DELTA-9去饱和酶
-
申请号： US12744062申请日： 2008-12-09
-
公开(公告)号： US20100249192A1公开(公告)日： 2010-09-30
- 发明人: Chun Sing Li , Yeeman K. Ramtohul , Jean-Philippe Leclerc
- 申请人： Chun Sing Li , Yeeman K. Ramtohul , Jean-Philippe Leclerc
- 专利权人： MERCK FROSST CANADA LTD.
- 当前专利权人： MERCK FROSST CANADA LTD.
- 国际申请： PCT/CA08/02156 WO 20081209
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D413/04 ; A61K31/422 ; A61P3/10 ; A61P3/04 ; A61P1/16 ; A61P3/06 ; A61P9/10 ; C07D413/14 ; C07D403/04 ; A61K31/4192 ; A61K31/41
摘要：
Heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis. HetAr−W−X−Ar (I)
信息查询
IPC分类:
