发明申请
- 专利标题: Novel Compound Having Affinity to Amyloid
- 专利标题(中): 具有淀粉样蛋白亲和力的新型化合物
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申请号: US12226561申请日: 2007-04-26
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公开(公告)号: US20100249407A1公开(公告)日: 2010-09-30
- 发明人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki
- 申请人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki
- 申请人地址: JP TOKYO
- 专利权人: NIHON MEDI-PHYSICS CO., LTD.
- 当前专利权人: NIHON MEDI-PHYSICS CO., LTD.
- 当前专利权人地址: JP TOKYO
- 优先权: JP2006-124811 20060428
- 国际申请: PCT/JP2007/059048 WO 20070426
- 主分类号: C07F7/22
- IPC分类号: C07F7/22 ; C07D471/04 ; C07D487/04 ; C07D487/00
摘要:
The invention relates to a compound which has affinity with amyloid, shows sufficiently rapid clearance from normal tissues and is suppressed in toxicity such as mutagenicity, and also relates to a low-toxic diagnostic agent for Alzheimer's disease containing the compound. The compound is represented by the following formula (1) or a salt thereof: wherein A1, A2, A3 and A4 independently represent a carbon or a nitrogen, andR3 is a group represented by the following formula: wherein R1 is a radioactive halogen substituent; m is an integer of 0 to 4; and n is an integer of 0 or 1, provided that at least one of A1, A2, A3 and A4 represents a carbon, and R3 binds to a carbon represented by A1, A2, A3 or A4.
公开/授权文献
- US08022207B2 Compound having affinity to amyloid 公开/授权日:2011-09-20
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