发明申请
- 专利标题: NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID
- 专利标题(中): 具有AMYLOID亲和性的新化合物
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申请号: US12739348申请日: 2008-10-24
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公开(公告)号: US20100249418A1公开(公告)日: 2010-09-30
- 发明人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- 申请人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- 申请人地址: JP Tokyo
- 专利权人: NIHON MEDI-PHYSICS CO., LTD.
- 当前专利权人: NIHON MEDI-PHYSICS CO., LTD.
- 当前专利权人地址: JP Tokyo
- 优先权: JP2007-276826 20071024
- 国际申请: PCT/JP2008/069335 WO 20081024
- 主分类号: C07D471/04
- IPC分类号: C07D471/04
摘要:
A compound effective as a probe targeting amyloid for image diagnosis and a reagent comprising the compound for detecting amyloid deposited on a biological tissue are provided. Provided are a compound represented by the following formula (1): wherein R1 is a group selected from the group consisting of a halogen substituent, alkyl substituent with 1 to 4 carbon atoms, alkoxy substituent having alkyl chain with 1 to 4 carbon atoms and hydroxyl group, R2 is a group selected from the group consisting of a cyano substituent, alkyl substituent with 1 to 4 carbon atoms and halogen substituent, R3 is a group selected from the group consisting of a hydroxyl group, halogen substituent and substituent represented by the following formula: (wherein R4 is a hydrogen, halogen substituent or hydroxyl group, and m is an integer of 1 to 4), provided that at least one of R1, R2, R3 and R4 represents a radioactive halogen, and a reagent comprising the same.
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