发明申请
US20100254964A1 Modified Bouganin Proteins, Cytotoxins and Methods and Uses Thereof
有权
改良的Bouganin蛋白，细胞毒素及其用途
- 专利标题： Modified Bouganin Proteins, Cytotoxins and Methods and Uses Thereof
- 专利标题（中）： 改良的Bouganin蛋白，细胞毒素及其用途
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申请号： US12784820申请日： 2010-05-21
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公开(公告)号： US20100254964A1公开(公告)日： 2010-10-07
- 发明人: Matthew Baker , Francis J. Carr , Koen Hellendoorn , Jeannick Cizeau , Glen Christopher MacDonald , Joycelyn Entwistle , Denis Georges Bosc , Nicholas Ronald Glover
- 申请人： Matthew Baker , Francis J. Carr , Koen Hellendoorn , Jeannick Cizeau , Glen Christopher MacDonald , Joycelyn Entwistle , Denis Georges Bosc , Nicholas Ronald Glover
- 主分类号： A61K38/47
- IPC分类号： A61K38/47 ; A61P35/00
摘要：
The invention provides modified forms of bouganin protein having biological activity and a reduced propensity to activate human T cells as compared to the non-modified bouganin protein. The invention also provides T-cell epitope peptides of bouganin, and modified T-cell epitope peptides of bouganin which have a reduced propensity to activate human T cells as compared to the non-modified T-cell epitope peptide. The invention also provides cytotoxins having the having a ligand that binds to a cancer cells attached to the modified bouganin proteins. Also provided are methods of inhibiting or destroying mammalian cancer cells using the cytotoxins of the invention and pharmaceutical compositions for treating human cancer.
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