发明申请
US20100256014A1 NOVEL AS160-LIKE PROTEIN, TEST SYSTEMS, METHODS AND USES INVOLVING IT FOR THE IDENTIFICATION OF DIABETES TYPE 2 THERAPEUTICS
审中-公开
新型AS160型蛋白质，测试系统，涉及其用于鉴定糖尿病2型治疗药物的方法和用途
- 专利标题： NOVEL AS160-LIKE PROTEIN, TEST SYSTEMS, METHODS AND USES INVOLVING IT FOR THE IDENTIFICATION OF DIABETES TYPE 2 THERAPEUTICS
- 专利标题（中）： 新型AS160型蛋白质，测试系统，涉及其用于鉴定糖尿病2型治疗药物的方法和用途
-
申请号： US12667772申请日： 2008-07-23
-
公开(公告)号： US20100256014A1公开(公告)日： 2010-10-07
- 发明人: Norbert Tennagels , Daniela Baus , Kathrin Heermeier , Werner Dittrich
- 申请人： Norbert Tennagels , Daniela Baus , Kathrin Heermeier , Werner Dittrich
- 申请人地址： FR Paris
- 专利权人： SANOFI-AVENTIS
- 当前专利权人： SANOFI-AVENTIS
- 当前专利权人地址： FR Paris
- 优先权： EP07015086.7 20070801
- 国际申请： PCT/EP08/06024 WO 20080723
- 主分类号： C12Q1/54
- IPC分类号： C12Q1/54 ; C40B30/06 ; C12Q1/68 ; C07K14/435 ; C07H21/04 ; C07K16/18 ; C12N5/10
摘要：
The present invention relates to novel AKT substrate 160 kDa-like protein (AS160-like protein), to a method of identifying a substance altering glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell comprising contacting a test system comprising AKT substrate 160 kDa-like protein (AS160-like protein) with a test substance, and identifying a test substance as a substance altering glucose uptake of a cell by detecting a signal indicative for altered glucose uptake of a cell; a test system comprising a gene coding for the AKT substrate 160 kDa-like protein (AS 160-like protein) and an inducible promoter providing for controllable expression of the gene; the use of the test system for the identification of a substance improving glucose uptake and/or GLUT4 translocation to the plasma membrane of a cell; and the use of AS160-like protein in a model for type 2 diabetes.
信息查询
