发明申请
- 专利标题： SUBSTITUTED ISOXAZOLES
- 专利标题（中）： 取代的ISOXAZOLES
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申请号： US12748524申请日： 2010-03-29
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公开(公告)号： US20100256127A1公开(公告)日： 2010-10-07
- 发明人: Bernd Buettelmann , Stephen Deems Gabriel , Steven Paul Hanlon , Roland Jakob-Roetne , Matthew C. Lucas , Paul Spurr , Andrew Thomas , Pius Waldmeier
- 申请人： Bernd Buettelmann , Stephen Deems Gabriel , Steven Paul Hanlon , Roland Jakob-Roetne , Matthew C. Lucas , Paul Spurr , Andrew Thomas , Pius Waldmeier
- 优先权： EP09157200.8 20090402
- 主分类号： A61K31/465
- IPC分类号： A61K31/465 ; C07D413/12 ; C07D417/14 ; A61K31/541 ; C07D413/14 ; A61K31/5377 ; A61P25/28
摘要：
The present invention is concerned with novel hydroxy-methyl isoxazole derivatives of formula I wherein R1, R2 and R3 are as described herein, as well as pharmaceutically acceptable salts and esters thereof. The active compounds of the present invention have affinity and selectivity for GABA A α5 receptor. Further the present invention is concerned with the manufacture of the active compounds of formula I, pharmaceutical compositions containing them and their use as pharmaceuticals.
公开/授权文献
- US08222246B2 Substituted isoxazoles 公开/授权日：2012-07-17
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