发明申请
- 专利标题： NOVEL SALT OF 1,3,5-TRIAZINE-2,4,6-TRIAMINE DERIVATIVE
- 专利标题（中）： 1,3,5-三氮杂-2,4,6-三胺衍生物的新型盐
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申请号： US12753415申请日： 2010-04-02
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公开(公告)号： US20100256151A1公开(公告)日： 2010-10-07
- 发明人: Junya OHMORI , Makoto KASAI , Takenori KIMURA , Noritaka HAMADA , Ryo MIZOGUCHI , Satoshi MIYAMOTO , Noriyuki KAWANO
- 申请人： Junya OHMORI , Makoto KASAI , Takenori KIMURA , Noritaka HAMADA , Ryo MIZOGUCHI , Satoshi MIYAMOTO , Noriyuki KAWANO
- 申请人地址： JP Tokyo
- 专利权人： ASTELLAS PHARMA INC.
- 当前专利权人： ASTELLAS PHARMA INC.
- 当前专利权人地址： JP Tokyo
- 主分类号： A61K31/53
- IPC分类号： A61K31/53 ; C07D403/12 ; A61P25/28
摘要：
Anytime obtained is uniform crystal of N-(4-fluorophenyl)-N′-phenyl-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound A) and/or N,N′-bis (4-fluorophenyl)-N″-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine (compound B) as a medicament or a starting material for the preparation of the medicament, and provided are a fumarate of the compound A and/or the compound B having excellent stability and a novel crystal thereof. A salt of the compound A and/or the compound B with fumaric acid enables uniform crystal to be anytime obtained, and thus, it is a compound that is very useful as a medicament or a starting material for the preparation of the medicament having excellent stability.
公开/授权文献
- US08399663B2 Salt of 1,3,5-triazine-2,4,6-triamine derivative 公开/授权日：2013-03-19