The invention is an Intelligent Conveyor Adjustment System (ICAS). The ICAS gives the user a way to adjust guide rails and other devices used in a conveyor system with actuators that can receive instructions based on a specific communications interface, such an interface may consist of but is not limited to serial wired network, an 802.11 compatible network, a power line network, and as described in the examples a wireless network, in a fashion to position rails or other devices on a conveyor system or in machines associated with a conveyor system. The actuators can be but are not limited to varying types, linear, rotary, push/pull covered cable, flexible strips, lever, pivoting, scissor, or other dual actuating mechanisms. The ACMs are used to control the actuators which control the relative position and shape of guide rails on the sides of the conveyor as well as position of various other conveyor entities such as, but not limited to, timing screws, labelers, marking machines, barcode readers, and fillers.