发明申请
- 专利标题： Factor VII or VIIa Polypeptide Variants
- 专利标题（中）： 因子VII或VIIa多肽变体
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申请号： US12707453申请日： 2010-02-17
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公开(公告)号： US20100260741A1公开(公告)日： 2010-10-14
- 发明人: Jesper Mortensen Haaning , Kim Vilbour Andersen
- 申请人： Jesper Mortensen Haaning , Kim Vilbour Andersen
- 专利权人： BAYER HEALTHCARE LLC
- 当前专利权人： BAYER HEALTHCARE LLC
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; C12N9/96 ; A61P7/04
摘要：
The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N-glycosylation site located outside of the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma.
公开/授权文献
- US09353365B2 Factor VII or VIIa polypeptide variants 公开/授权日：2016-05-31
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