发明申请
- 专利标题: CHEMICAL COMPOUNDS
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申请号: US12665128申请日: 2008-07-01
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公开(公告)号: US20100261719A1公开(公告)日: 2010-10-14
- 发明人: Gregory Steven Basarab , Jacques Dumas , Pamela Hill
- 申请人: Gregory Steven Basarab , Jacques Dumas , Pamela Hill
- 国际申请: PCT/GB08/50530 WO 20080701
- 主分类号: A61K31/5383
- IPC分类号: A61K31/5383 ; C07D498/20 ; A61P31/04
摘要:
In one aspect, the present invention relates to compounds of Formula (I) and to pharmaceutically acceptable salts thereof, wherein: n is 1 to 4; and R3 in each occurrence is independently selected from —X—R5, —W—R6, —C(O)—N(R3a)—S(O)2—R3b, —C(R3a)═N—R3y, C(R3a)═N—N(R3a)—C(O)—R3b, C(R3a)═N—N(R3a)—C(O)2—R3b, —C(R3a)═N—N(R3y)2, —C(R3a)═N—N(R3a)—C(O)—N(R3y)2, —C(NR3a)2)═N—R3y, —C(N(R3a)2)═N—OR3y, —C(N(R3a)2)═N—C(O)—R3b, —C(N(R3a)2═N—S(0)2—R3b, —C(N(R3a)2)═N—CN, —N═C(R3y)2, —N(R3a)—S(O)2—N(R3y)2, —N(R3a)—N(R3y2, —N(R3a)—C(O)—N(R3y)2, —N(R3a)—C(O)—N(R3a)—S(O)2—R3b, —N(R3a)—C(R3a)═N(R3y), —N(R3a)—C(R3a)═N—OR3y, —N(R3a)—C(R3a)═N—C(O)—R3b, —N(R3a)—C(R3a)═N—S(O)2R—3b, —N(R3a)—C(R3a)═N—CN, —N(R3a)—C(N(R3a)2)═N—R3y, —N(R3a)—C(N(R3a)2)═N—OR3y, —N(R3a)—C(N(R3a)2)═N—C(O)—R3b, —N(R3a)—C(N(R3a)2)—N—S(O)2—R3b, —N(R3a)—C(N(R3a)2)—N—CN, —O—C(O)—R3, and —Si(R3b)3; to methods of using them to treat bacterial infections, and to methods for their preparation.
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