发明申请
- 专利标题： SMAC MIMETIC COMPOUNDS AS APOPTOSIS INDUCERS
- 专利标题（中）： 作为APOPTOSIS诱导剂的SMAC物质化合物
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申请号： US12741862申请日： 2008-11-05
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公开(公告)号： US20100267692A1公开(公告)日： 2010-10-21
- 发明人: Carlo Scolastico , Leonardo Pierpaolo Manzoni , Pierfausto Seneci , Laura Belvisi , Domenico Delia , Martino Bolognesi , Eloise Mastrangelo , Mario Milani , Ilaria Motto , Carmelo Drago
- 申请人： Carlo Scolastico , Leonardo Pierpaolo Manzoni , Pierfausto Seneci , Laura Belvisi , Domenico Delia , Martino Bolognesi , Eloise Mastrangelo , Mario Milani , Ilaria Motto , Carmelo Drago
- 优先权： EP07021843.3 20071109
- 国际申请： PCT/IB08/02971 WO 20081105
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D487/14 ; C07D487/04 ; A61P35/00
摘要：
The present invention relates to compounds conformationally constrained mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients.
公开/授权文献
- US08609685B2 SMAC mimetic compounds as apoptosis inducers 公开/授权日：2013-12-17