发明申请
US20100267724A2 S-TRIAZOLE ALPHA-MERCAPTOACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
有权
作为艾滋病毒逆转录酶的抑制剂的S-三唑阿尔法 - 卡培他他胺
- 专利标题: S-TRIAZOLE ALPHA-MERCAPTOACETANILIDES AS INHIBITORS OF HIV REVERSE TRANSCRIPTASE
- 专利标题(中): 作为艾滋病毒逆转录酶的抑制剂的S-三唑阿尔法 - 卡培他他胺
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申请号: US11661079申请日: 2008-03-20
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公开(公告)号: US20100267724A2公开(公告)日: 2010-10-21
- 发明人: Jean-Luc Girardet , Yung-Hyo Koh , Martha De La Rosa , Esmir Gunic , Zhi Hong , Stanley Lang , Woo-Hong Kim
- 申请人: Jean-Luc Girardet , Yung-Hyo Koh , Martha De La Rosa , Esmir Gunic , Zhi Hong , Stanley Lang , Woo-Hong Kim
- 申请人地址: US CA San Diego 92121
- 专利权人: Ardea Biosciences, Inc.
- 当前专利权人: Ardea Biosciences, Inc.
- 当前专利权人地址: US CA San Diego 92121
- 优先权: WOPCT/US2005/030259 20050825
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D249/12 ; C07D413/02 ; A61K31/454 ; A61P31/18 ; C07D401/04 ; A61K31/4196
摘要:
A series of S-triazolyl α-mercaptoacetanilides having general structure (1) are provided, where Q is CO2H, CONR2, SO3H, or SO2NR2. The compounds inhibit several variants of the reverse transcriptase of HIV, and are useful in the treatment of HIV infections.