The current invention provides an ultrasound-assisted delivery device, that includes a focused ultrasound transducer having an ultrasound focal point, a real-time imaging device having an imaging focal point, and a therapeutic delivery device, where the transducer and the imaging device are integrated with the delivery device, and the ultrasound focal point coincides with the imaging focal point, where the delivery device and transducer are disposed to provide an unobstructed imaging path for the real-time imaging device. The invention further includes a scanning optical or laser beam having a focal point disposed to sweep across the target, where the delivery device is disposed to deliver an optical contrast material to the target, and the scanning focal point coincides with the ultrasound and imaging focal points, where the target or the optical contrast material react to the scanning beam to generate at least one interface signal.