A wake-and-go mechanism is provided for a data processing system. The wake-and-go mechanism detects a thread running on a first processing unit within a plurality of processing units that is waiting for an event that modifies a data value associated with a target address. The wake-and-go mechanism creates a wake-and-go instance for the thread by populating a wake-and-go storage array with the target address. The operating system places the thread in a sleep state. Responsive to detecting the event that modifies the data value associated with the target address, the wake-and-go mechanism assigns the wake-and-go instance to a second processing unit within the plurality of processing units. The operating system on the second processing unit places the thread in a non-sleep state.