发明申请
US20100273772A1 Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5)
审中-公开
双芳基炔基酰胺作为代谢型谷氨酸受体5（MGLUR5）的负变构调节剂
- 专利标题： Bisaryl Alkynylamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5 (MGLUR5)
- 专利标题（中）： 双芳基炔基酰胺作为代谢型谷氨酸受体5（MGLUR5）的负变构调节剂
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申请号： US12765068申请日： 2010-04-22
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公开(公告)号： US20100273772A1公开(公告)日： 2010-10-28
- 发明人: Steven Victor O'Neil , Benjamin Miller Zegarelli , Dane Mark Springer , David Zenan Li
- 申请人： Steven Victor O'Neil , Benjamin Miller Zegarelli , Dane Mark Springer , David Zenan Li
- 申请人地址： US NJ Madison
- 专利权人： Wyeth LLC
- 当前专利权人： Wyeth LLC
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K31/553
- IPC分类号： A61K31/553 ; C07D401/10 ; A61K31/4439 ; A61K31/4725 ; C07D487/04 ; A61K31/4985 ; C07D267/14 ; C07D243/14 ; A61K31/5513 ; C07D223/16 ; A61K31/55 ; C07D471/04 ; A61K31/4375 ; C07D209/44 ; A61K31/4035 ; A61P25/00 ; A61P29/00
摘要：
Disclosed are compounds of Formula I: pharmaceutical compositions containing compounds of Formula I, and the use of compounds of Formula I to treat diseases and disorders including schizophrenia, paranoia, depression, manic-depressive illness and anxiety wherein W1-W5, X1-X4, Y, Z1-Z5, m, n, p, and R1-R6 in Formula I are defined in the specification.
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