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发明申请
US20100274003A1 ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME 审中-公开
碳水化合物抗生素合成中间体的添加剂量及其制备方法

ACID ADDITION SALTS OF SYNTHETIC INTERMEDIATES FOR CARBAPENEM ANTIBIOTICS AND PROCESSES FOR PREPARING THE SAME
摘要：
The present invention provides a process for preparing an acid addition salt of a synthetic intermediate for carbapenem antibiotics and a novel acid addition salt of a synthetic intermediate for carbapenem antibiotics obtained from the process. The present invention also provides a process for preparing a carbapenem antibiotic using the acid addition salt. According to the process of the present invention, an acid addition salt of a synthetic intermediate for carbapenem antibiotics can be prepared in a high yield and high purity, without conducting column chromatography. Thus, the process of the present invention can be applied to mass production with an industrial scale. Furthermore, since the acid addition salts have solid forms, they are easy to handle and keep in a manufacturing site.
摘要（中）：

本发明提供了一种制备碳青霉烯类抗生素合成中间体的酸加成盐的方法和由该方法得到的碳青霉烯类抗生素合成中间体的新型酸加成盐。 本发明还提供了使用酸加成盐制备碳青霉烯类抗生素的方法。 根据本发明的方法，可以以高产率和高纯度制备碳青霉烯类抗生素合成中间体的酸加成盐，而不进行柱层析。 因此，本发明的方法可以应用于工业规模的批量生产。 此外，由于酸加成盐具有固体形式，因此易于处理并保持在制造现场。

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