发明申请
US20100280015A1 NOVAL 1,4-DIAZA-BICLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
审中-公开
NOVAL 1,4-DIAZA-BICLO [3.2.2] NONYL OXADIAZOLYL DERIVATIVES有用作为NICOTINIC乙酰胆碱受体配体
![NOVAL 1,4-DIAZA-BICLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS](/docs/US/2010-11-04/US20100280015A1/abs.jpg.600x600.jpg)
- 专利标题： NOVAL 1,4-DIAZA-BICLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS
- 专利标题（中）： NOVAL 1,4-DIAZA-BICLO [3.2.2] NONYL OXADIAZOLYL DERIVATIVES有用作为NICOTINIC乙酰胆碱受体配体
-
申请号： US12733175申请日： 2008-08-14
-
公开(公告)号： US20100280015A1公开(公告)日： 2010-11-04
- 发明人: Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen
- 申请人： Dan Peters , Daniel B. Timmermann , Elsebet Østergaard Nielsen , Gunnar M. Olsen , Tino Dyhring , Jeppe Kejser Christensen
- 申请人地址： DK Ballerup
- 专利权人： NeuroSearch A/S
- 当前专利权人： NeuroSearch A/S
- 当前专利权人地址： DK Ballerup
- 优先权： DKPA200701174 20070817
- 国际申请： PCT/EP2008/060653 WO 20080814
- 主分类号： A61K31/551
- IPC分类号： A61K31/551 ; C07D487/08 ; A61P25/00 ; A61P25/28 ; A61P25/18 ; A61P25/24 ; A61P29/00 ; A61P25/30 ; A61P1/12 ; A61P3/00 ; A61P9/12 ; A61P15/00 ; A61P17/00
![NOVAL 1,4-DIAZA-BICLO[3.2.2]NONYL OXADIAZOLYL DERIVATIVES USEFUL AS NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS](/abs-image/US/2010/11/04/US20100280015A1/abs.jpg.150x150.jpg)
摘要：
This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl oxadiazolyl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.
信息查询
