发明申请
- 专利标题： PYRIDOPYRIMIDINE PROTEIN TYROSINE PHOSPHATASE INHIBITORS
- 专利标题（中）： 吡啶酮嘧啶蛋白酪氨酸磷酸酶抑制剂
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申请号： US12837558申请日： 2010-07-16
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公开(公告)号： US20100280021A1公开(公告)日： 2010-11-04
- 发明人: Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
- 申请人： Steven Joseph Berthel , Adrian Wai-Hing Cheung , Kyungjin Kim , Shiming Li , Kshitij Chhabilbhai Thakkar , Weiya Yun
- 主分类号： A61K31/541
- IPC分类号： A61K31/541 ; C07D471/04 ; A61K31/519 ; A61K31/5377 ; A61P3/10
摘要：
The present invention comprises pyridopyrimidinediamine compounds of the general formula I: The compounds of the present invention are potent inhibitors of PTP1B. Accordingly, the invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
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