发明申请
US20100280048A1 Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
失效
一些2-吡嗪酮衍生物及其作为嗜中性粒细胞弹性蛋白酶抑制剂的用途
- 专利标题： Some 2-pyrazinone derivatives and their use as inhibitors of neutrophile elastase
- 专利标题（中）： 一些2-吡嗪酮衍生物及其作为嗜中性粒细胞弹性蛋白酶抑制剂的用途
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申请号： US12740136申请日： 2008-11-05
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公开(公告)号： US20100280048A1公开(公告)日： 2010-11-04
- 发明人: Debra Ainge , David Chapman , Martin Lindsjo , Hans Lonn , Michael Lundkvist , Magnus Munck AF Rosen-Schold , Antonios Nikitidis , John Pavey
- 申请人： Debra Ainge , David Chapman , Martin Lindsjo , Hans Lonn , Michael Lundkvist , Magnus Munck AF Rosen-Schold , Antonios Nikitidis , John Pavey
- 申请人地址： SE Sodertalje
- 专利权人： ASTRAZENECA R&D
- 当前专利权人： ASTRAZENECA R&D
- 当前专利权人地址： SE Sodertalje
- 国际申请： PCT/SE2008/051263 WO 20081105
- 主分类号： A61K31/497
- IPC分类号： A61K31/497 ; C07D403/04 ; C07D401/14 ; A61P29/00 ; A61P11/00 ; A61P9/12 ; A61P11/06 ; A61P9/10 ; A61P17/06 ; A61P35/00
摘要：
The invention provides certain novel 6-heteroaryl-5-methyl-3-oxo-4-[3(trifluoromethyl)phenyl]-3,4-dihydropyrazine-2-carboxamide derivatives and pharmaceutically acceptable salts thereof and particular Forms thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.