发明申请
US20100284995A1 Temperature sensitive mutants of matrix metalloproteases and uses thereof
审中-公开
基质金属蛋白酶的温度敏感突变体及其用途
- 专利标题： Temperature sensitive mutants of matrix metalloproteases and uses thereof
- 专利标题（中）： 基质金属蛋白酶的温度敏感突变体及其用途
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申请号： US12660894申请日： 2010-03-05
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公开(公告)号： US20100284995A1公开(公告)日： 2010-11-11
- 发明人: Louis Bookbinder , Gregory I. Frost , Gilbert Keller , Gerhard Johann Frey , Hwai Wen Chang , Jay Milton Short
- 申请人： Louis Bookbinder , Gregory I. Frost , Gilbert Keller , Gerhard Johann Frey , Hwai Wen Chang , Jay Milton Short
- 主分类号： A61K38/48
- IPC分类号： A61K38/48 ; A61K38/47 ; A61P17/02 ; A61P19/00 ; A61P17/00 ; C12N9/50 ; C12N9/96 ; C07H21/04 ; C12N15/63 ; C12N5/10
摘要：
Provided are modified matrix metalloprotease (MMP) enzymes that exhibit temperature-dependent activity and uses thereof. The MMPs can be used, for example, to treat ECM-mediated diseases or disorders characterized by increased deposition or accumulation of one or more ECM components.