发明申请
US20100285132A1 IMMUNOTHERAPY COMPOSITIONS, METHOD OF MAKING AND METHOD OF USE THEREOF
审中-公开
免疫组合物，制备方法及其使用方法
- 专利标题： IMMUNOTHERAPY COMPOSITIONS, METHOD OF MAKING AND METHOD OF USE THEREOF
- 专利标题（中）： 免疫组合物，制备方法及其使用方法
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申请号： US12562432申请日： 2009-09-18
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公开(公告)号： US20100285132A1公开(公告)日： 2010-11-11
- 发明人: Russell G. Higbee , Glen N. Barber
- 申请人： Russell G. Higbee , Glen N. Barber
- 申请人地址： US FL Miami US FL Orlando
- 专利权人： University Of Miami,Vaxdesign Corporation
- 当前专利权人： University Of Miami,Vaxdesign Corporation
- 当前专利权人地址： US FL Miami US FL Orlando
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61K39/00 ; A61K39/02 ; A61K39/12 ; A61K9/14 ; A61K9/00 ; A61K38/21 ; A61P31/12 ; A61P31/16 ; A61P31/18 ; A61P35/00
摘要：
The present invention directs to compositions and methods for modulating immune system. One aspect of the present invention relates to a composition comprising FADD-dependent signaling pathway modulators. Another aspect of the 5 present invention relates to biodegradable microparticles, such as a chitosan microparticic, or PLGA/PEI microparticle, designed to deliver nucleic acids and/or proteins, such as FADD-dependent signaling pathway modulators, to boost different pathways of an immune response. Another aspect of the present invention relates to the method of making biodegradable microparticles. The further aspect of the present invention relates to the use of the chitosan and other polycationic microparticles to deliver FADD-dependent signaling pathway modulators to modulate immune system for the prevention and/or treatment infectious diseases and cancers.
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