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发明申请
US20100286088A1 3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d][1,2,3,5-Tetrazine-8-Carboxylic Acid Amides and Their Use 有权
3-取代-4-氧代-3,4-二氢咪唑并[5,1-d] [1,2,3,5-四嗪-8-羧酸酰胺及其用途

3-Substituted-4-Oxo-3,4-Dihydro-Imidazo[5,1-d][1,2,3,5-Tetrazine-8-Carboxylic Acid Amides and Their Use
摘要：
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.
摘要（中）：

本发明一般涉及治疗化合物领域，更具体地涉及某些3-取代-4-氧代-3,4-二氢 - 咪唑并[5,1-d] [1,2,3,5]四嗪 - 8-羧酸酰胺（本文统称为3TM化合物）。 本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内都用于抑制细胞增殖以及治疗增殖性疾病例如癌症等的用途，以及 制备此类化合物。

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