发明申请
US20100286151A1 1-OXA-3-Azaspiro[4,5]Decan--2-One Derivatives For The Treatment Of Eating Disorders
审中-公开
1-OXA-3-Azaspiro [4,5] Decan-2-One衍生物治疗饮食失调
- 专利标题: 1-OXA-3-Azaspiro[4,5]Decan--2-One Derivatives For The Treatment Of Eating Disorders
- 专利标题(中): 1-OXA-3-Azaspiro [4,5] Decan-2-One衍生物治疗饮食失调
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申请号: US12524080申请日: 2008-01-30
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公开(公告)号: US20100286151A1公开(公告)日: 2010-11-11
- 发明人: Jonathan Bentley , Matteo Biagetti , Romano Di Fabio , Thorsten Genski , Sebastien Guery , Silvia Rosalia Kopf , Colin philip Leslie , Angelica Mazzali , Sergio Melotto , Domenica Antonia Pizzi , Fabio Maria Sabbatini , Catia Seri
- 申请人: Jonathan Bentley , Matteo Biagetti , Romano Di Fabio , Thorsten Genski , Sebastien Guery , Silvia Rosalia Kopf , Colin philip Leslie , Angelica Mazzali , Sergio Melotto , Domenica Antonia Pizzi , Fabio Maria Sabbatini , Catia Seri
- 优先权: GB0701962.3 20070201; GB0720880.4 20071024; GB0800267.7 20080108
- 国际申请: PCT/EP08/51111 WO 20080130
- 主分类号: A61K31/423
- IPC分类号: A61K31/423 ; C07D417/14 ; A61K31/4439 ; A61K31/505 ; C07D413/14 ; A61K31/501 ; A61K31/444 ; A61K31/497 ; A61K31/433 ; C07D471/04 ; A61K31/437 ; C07D487/04 ; A61K31/4985 ; C07D413/12 ; A61P3/04 ; A61P3/00
摘要:
The present invention relates to novel compounds of formula (I), or a pharmaceutically acceptable salt or solvate thereof, wherein R is an aryl or heteroaryl; which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; Z1 is H, C1-C4 alkyl or F; Z is CH2, CH(C1-C4 alkyl), C(C1-C4 alkyl)2 or a bond; A is a 5 membered heteroaryl, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, Cl C4 haloalkoxy, cyano; B is hydrogen or is a 5-6 membered heteroaryl, or phenyl, which may be substituted by one or more: halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, C1-C4 haloalkoxy, cyano; being A and B linked via any atom; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as NPY Y5 receptor antagonists and as agents for the treatment and/or prophylaxis of eating disorders such as a binge eating disorder.
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